Robust Classification for Imprecise Environments

In real-world environments it usually is difficult to specify target operating conditions precisely, for example, target misclassification costs. This uncertainty makes building robust classification systems problematic. We show that it is possible to build a hybrid classifier that will perform at least as well as the best available classifier for any target conditions. In some cases, the performance of the hybrid actually can surpass that of the best known classifier. This robust performance extends across a wide variety of comparison frameworks, including the optimization of metrics such as accuracy, expected cost, lift, precision, recall, and workforce utilization. The hybrid also is efficient to build, to store, and to update. The hybrid is based on a method for the comparison of classifier performance that is robust to imprecise class distributions and misclassification costs. The ROC convex hull (ROCCH) method combines techniques from ROC analysis, decision analysis and computational geometry, and adapts them to the particulars of analyzing learned classifiers. The method is efficient and incremental, minimizes the management of classifier performance data, and allows for clear visual comparisons and sensitivity analyses. Finally, we point to empirical evidence that a robust hybrid classifier indeed is needed for many real-world problems.Comment: 24 pages, 12 figures. To be published in Machine Learning Journal. For related papers, see http://www.hpl.hp.com/personal/Tom_Fawcett/ROCCH

A Guide to Writing Letters to Public Officials: Contributing to Important Decisions Affecting You and Others

A well-written personal letter may be the most effective way to communicate with public officials. They want to know how their constituents feel about issues, especially when those issues involve decisions by elected officials. Public officials usually know what lobbying groups are saying about an issue, but often they do not understand how a particular decision affects you. A well-written letter describing your experiences, observations, and opinions may change an official’s mind. The same guidelines are also useful for writing to private officials such as business owners, executives of groups like the chamber of commerce, or presidents of corporate boards of directors. These individuals can also make decisions that affect you or the public. You can write two types of letters – positive or negative. A positive letter explains why a decision is or would be good. You should write positive letters about favorable decisions. A negative letter explains your opposition to a pending decision. Writing effective letters builds your reputation as a thoughtful person in the eyes of officials and makes your criticisms more influential. This guide is designed to help you prepare effective letters. It includes examples of a positive letter and one that criticizes a pending decision. Specific steps for writing an effective letter are also described. Then you will write your own letter

A Guide to Writing Letters to the Editor: Expressing Your Opinion to the Public Effectively

One way to express your opinion publicly is through a letter to the editor in your local newspaper. While every letter may not be published, editors pay attention to well-written letters. This is especially true when there are many letters written on the same topic. In turn, elected officials are also influenced by letters newspapers have chosen for publication. This guide will help you prepare an effective letter to the editor that expresses your opinion on an issue. It includes two letters about a controversial issue and specific guidelines on how to prepare a successful letter yourself. After you read the guide, prepare a letter yourself. Let a friend read it for clarity. Be sure to sign the letter and list your address – newspapers will not publish anonymous letters. Your letter can be positive, negative or informative in tone. It can also be emotional or objective. But it should be simple and short – rarely more than 300 words. And, of course, it should reflect your true opinions

A Guide for Personal Testimony: The Art of Using Your Personal Experiences to Influence Policy Decisions

The quality of life in any community is determined to some extent by the laws and policies of governmental units and agencies. One way of changing community conditions is to change the laws and policies. From a group’s perspective, any proposed change may be for the better or the worse. However, for changes in laws, regulations, or policies to occur, a public hearing is often required. During public hearings, people have an equal opportunity speak either for or against proposed changes. Many different types of testimony can be and usually are provided during public hearings. These may range from detailed, expert testimony using facts and figures to brief, personal testimony using personal experiences. Each type of testimony has great importance, because public officials often judge the importance of an issue by the number and type of comments they hear. The purpose of brief, personal testimony is to help those making the decision understand the issues in human or personal terms. As someone interested in giving personal testimony, your task is to tell a story about the changes being considered: to tell what they mean to you. This is not an easy task. It is never easy to talk about important things in limited time, and the issues may be very emotional ones. This testimony guide is designed to help you prepare your testimony and to teach you how to present it successfully

Electrochemical Synthesis, Characterisation, and Preliminary Biological Evaluation of an Anodic Aluminium Oxide Membrane with a pore size of 100 nanometres for a Potential Cell Culture Substrate

Abstract In this study we investigate the electrochemical synthesis and characterisation of a nanometre scale porous anodic alumin iu m o xide (AAO) membranes with a mean pore diameter of 100 n m. The membranes exhib it interesting properties such as controllable pore diameters, periodicity and density distribution. These properties can be preselected by adjusting the controlling parameters of a temperature controlled two-step anodization process. The surface features of the nanometre scale memb rane such as pore density, pore diameter and inter-pore d istance were quantified using field emission scanning electron microscopy (FESEM) and ato mic fo rce microscopy (AFM). A preliminary bio logical evaluation of the memb ranes was carried out to determine cell adhesion and morphology using the Cercopithecus aethiops[African green monkey -(Vero)] kidney epithelial cell line. Optical microscopy, FESEM and AFM investigations revealed the presence of focal adhesion sites over the surface of the porous membranes. The positive outcomes of the study, indicates that AAO memb ranes can be used as a viable tissue scaffold for potential tissue engineering applications in the future

Recommendations of the task force on public policy

This is the published version, reproduced here with permission from the publisher. This article is also available electronically from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741851/.The Task Force on Public Policy was established by the Association for Behavior Analysis to examine ways to encourage members to contribute to policymaking relevant to the public interest. Members discussed issues pertinent to this activity and summarized their discussion in a formal report.' Recommendations of the Task Force for conducting and disseminating policy research and for training, technical assistance, and other services supportive of behavior-analytic research in the public policy arena are presented here

Neural mechanisms of economic commitment in the human medial prefrontal cortex

Neurobiologists have studied decisions by offering successive, independent choices between goods or gambles. However, choices often have lasting consequences, as when investing in a house or choosing a partner. Here, humans decided whether to commit (by acceptance or rejection) to prospects that provided sustained financial return. BOLD signals in the rostral medial prefrontal cortex (rmPFC) encoded stimulus value only when acceptance or rejection was deferred into the future, suggesting a role in integrating value signals over time. By contrast, the dorsal anterior cingulate cortex (dACC) encoded stimulus value only when participants rejected (or deferred accepting) a prospect. dACC BOLD signals reflected two decision biases–to defer commitments to later, and to weight potential losses more heavily than gains–that (paradoxically) maximised reward in this task. These findings offer fresh insights into the pressures that shape economic decisions, and the computation of value in the medial prefrontal cortex. - See more at: http://elifesciences.org/content/3/e03701#sthash.rpmo51q5.dpu

Consensus statement for perioperative care in lumbar spinal fusion: Enhanced Recovery After Surgery (ERAS®) Society recommendations

BACKGROUND: Enhanced Recovery After Surgery (ERAS) evidence-based protocols for perioperative care have led to improvements in outcomes in numerous surgical areas, through multimodal optimization of patient pathway, reduction of complications, improved patient experience and reduction in the length of stay. ERAS represent a relatively new paradigm in spine surgery. PURPOSE: This multidisciplinary consensus review summarizes the literature and proposes recommendations for the perioperative care of patients undergoing lumbar fusion surgery with an ERAS program. STUDY DESIGN: This is a review article. METHODS: Under the impetus of the ERAS� society, a multidisciplinary guideline development group was constituted by bringing together international experts involved in the practice of ERAS and spine surgery. This group identified 22 ERAS items for lumbar fusion. A systematic search in the English language was performed in MEDLINE, Embase, and Cochrane Central Register of Controlled Trials. Systematic reviews, randomized controlled trials, and cohort studies were included, and the evidence was graded according to the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. Consensus recommendation was reached by the group after a critical appraisal of the literature. RESULTS: Two hundred fifty-six articles were included to develop the consensus statements for 22 ERAS items; one ERAS item (prehabilitation) was excluded from the final summary due to very poor quality and conflicting evidence in lumbar spinal fusion. From these remaining 21 ERAS items, 28 recommendations were included. All recommendations on ERAS protocol items are based on the best available evidence. These included nine preoperative, eleven intraoperative, and six postoperative recommendations. They span topics from preoperative patient education and nutritional evaluation, intraoperative anesthetic and surgical techniques, and postoperative multimodal analgesic strategies. The level of evidence for the use of each recommendation is presented. CONCLUSION: Based on the best evidence available for each ERAS item within the multidisciplinary perioperative care pathways, the ERAS� Society presents this comprehensive consensus review for perioperative care in lumbar fusion